経歴

• 1997.4〜2008.3 神戸大学
  • 工学部　応用化学科 プロセスシステム工学研究室
  • 自然科学研究科　応用化学専攻 プロセスシステム工学研究室 修士課程
  • 自然科学研究科　分子物質科学専攻 生物化学工学研究室 博士課程

• 2008.4〜2012.10　ヒューマン・メタボローム・テクノロジーズ株式会社
• 2012.11〜2013.12　味の素株式会社 イノベーション研究所
• 2014.4〜現在　ヒューマン・メタボローム・テクノロジーズ株式会社
• 主任(2014.4〜2018.3)、部長(2018.4〜現在)
• 2019.10〜2024.3　弘前大学大学院医学研究科メタボロミクスイノベーション学講座　特任准教授
• 2024.4〜現在(2026.3)　弘前大学大学院医学研究科 招へい准教授

学位論文

多変量解析を用いたメタボロームデータ解析に関する研究 (2008) 神戸大学大学院自然科学研究科　博士(工学)

本

• 山本博之,
  "質量分析インフォマティクスとケモインフォマティクスによる代謝物構造推定"
  ケモインフォマティクスにおけるデータ収集の最適化と解析手法,技術情報協会, 2023.
  [ link ]
• 山本博之,
  "メタボロミクスにおける「質量分析インフォマティクス」"
  バイオインフォマティクスの世界（別冊医学のあゆみ）,医歯薬出版, 2023.
  [ link ]
• 山本博之,
  "多変量解析，エンリッチメント解析，代謝マップ描画"
  メタボロミクス実践ガイド, 羊土社, 2021.
  [ link ]
• 山本博之,
  "メタボロームデータベースの構築の現状と創薬応用"
  in silico創薬におけるスクリーニングの高速化・高精度化技術, 技術情報協会, 2018.
  [ link ]
• Hiroyuki Yamamoto,
  "The Principal Component Analysis of Omics Data"
  Principal Component Analysis: Methods, Applications and Technology, Nova Science Publishers, 2017.
  [ link ]

プレプリント

• Hiroyuki Yamamoto
  "Single sample enrichment analysis for mass spectrometry-based omics data", Jxiv, (2023).
  [ link ]
  
• Hiroyuki Yamamoto
  "One-sided Kernel Principal Component Analysis", Jxiv, (2023).
  [ link ]
  
• Hiroyuki Yamamoto
  "Multiset partial least squares with rank order of groups for integrating multi-omics data", bioRxiv, (2022).
  [ link ]
  

論文

• Tetsuo Sugishita, Masanori Tokunaga, Kenjiro Kami, Kozue Terai, Hiroyuki Yamamoto, Hajime Shinohara, and Yusuke Kinugasa
  "Determination of the Minimum Sample Amount for Capillary Electrophoresis-Fourier Transform Mass Spectrometry (CE-FTMS)-Based Metabolomics of Colorectal Cancer Biopsies", Biomedicines, 11(6), (2023)1706.
  [ link ]
  
• Rira Matsuta, Hiroyuki Yamamoto*, Masaru Tomita, Rintaro Saito
  "iDMET: network-based approach for integrating differential analysis of cancer metabolomics.", BMC Bioinformatics, 23, 508 (2022).
  [ link (Pubmed)] (* corresponding author)
  
• Eiji Sasaki, Hiroyuki Yamamoto, Toru Asari, Rira Matsuta, Seiya Ota, Yuka Kimura, Shizuka Sasaki, Kyota Ishibashi, Yuji Yamamoto, Kenjiro Kami, Masataka Ando, Eiichi Tsuda, Yasuyuki Ishibashi
  "Metabolomics with severity of radiographic knee osteoarthritis and early phase synovitis in middle-aged women from the Iwaki Health Promotion Project: a cross-sectional study", Arthritis Research & Therapy, 24 (2022) 145.
  [ link (Pubmed)]
  
• Hiroyuki Yamamoto*, Makoto Suzuki, Rira Matsuta, Kazunori Sasaki, Moon-Il Kang, Kenjiro Kami, Yota Tatara, Ken Itoh* and Shigeyuki Nakaji
  "Capillary Electrophoresis Mass Spectrometry-Based Metabolomics of Plasma Samples from Healthy Subjects in a Cross-Sectional Japanese Population Study ", Metabolites, 11(5) (2021) 314.
  [ link (Pubmed)] (* corresponding author)
  
• Hiroyuki Yamamoto*, Yasumune Nakayama, Hiroshi Tsugawa
  "OS-PCA: Orthogonal Smoothed Principal Component Analysis Applied to Metabolome Data", Metabolites, 11(3) (2021) 149.
  [ link (Pubmed)] (* corresponding author)
  
• Yuichiro Nishida, Kazutoshi Nishijima, Yosuke Yamada, Hiroaki Tanaka, Akiko Matsumoto, Jianglin Fan, Yoichi Uda, Hajime Tomatsu, Hiroyuki Yamamoto, Kenjiro Kami, Shuji Kitajima and Keitaro Tanaka
  "Whole-body insulin resistance and energy expenditure indices, serum lipids, and skeletal muscle metabolome in a state of lipoprotein lipase overexpression.", Metabolomics, 17, (2021) 26.
  [ link (Pubmed)]
• Hiroshi Tsugawa, Ryo Nakabayashi, Tetsuya Mori, Yutaka Yamada, Mikiko Takahashi, Amit Rai, Ryosuke Sugiyama, Hiroyuki Yamamoto, Taiki Nakaya, Mami Yamazaki, Rik Kooke, Johanna Bac-Molenaar, Nihal Oztolan-Erol, Joost Keurentjes, Masnaori Arita, and Kazuki Saito
  "A cheminformatics approach to characterize metabolomes in stable isotope-labeled organisms", Nature Methods, 16 (2019) 295-298.
  [ link (Pubmed)]
• Kazunori Sasaki, Hitoshi Sagawa, Makoto Suzuki, Hiroyuki Yamamoto, Masaru Tomita, Tomoyoshi Soga, and Yoshiaki Ohashi
  "Metabolomics platform with capillary electrophoresis coupled with high-resolution mass spectrometry for plasma analysis", Analytical Chemistry, 91(2) (2019) 1295-1301.
  [ link (Pubmed)]
  
• Yoshihisa Wakita, Yumi Shimomura, Yusuke Kitada, Hiroyuki Yamamoto, Yoshiaki Ohashi, Mitsuharu Matsumoto,
  "Taxonomic classification for microbiome analysis, which correlates well with the metabolite milieu of the gut", BMC microbiology, 18:188 (2018)
  [ link (Pubmed)]
  
• Noriyuki Kawamura, Kosaku Shinoda, Hajime Sato, Kazunori Sasaki, Makoto Suzuki, Kumi Yamaki, Tamaki Fujimori, Hiroyuki Yamamoto, Douglas Osei-Hyiaman, Yoshiaki Ohashi,
  "Plasma metabolome analysis of patients with major depressive disorder.", Psychiatry and Clinical Neurosciences, 72(5) (2018) 349-361.
  [ link (Pubmed)]
  
• Hiroyuki Yamamoto,
  "PLS-ROG: Partial least squares with rank order of groups.", Journal of Chemometrics, 31(3) (2017) e2883.
  [ link / preprint (older version) ]
  
• Hiroyuki Yamamoto⁺*, Kazunori Sasaki⁺,
  "Metabolomics-based approach for ranking the candidate structures of unidentified peaks in capillary electrophoresis time-of-flight mass spectrometry", Electrophoresis, 38(7) (2017) 1053-1059.
  [ link (Pubmed) / cover picture ] (⁺ equally contributed, * corresponding author)
  
• Hiroyuki Yamamoto⁺, Kazuhiro Kondo⁺, Takayuki Tanaka, Takahiko Muramatsu, Hiroo Yoshida, Akira Imaizumi, Kenji Nagao, Yasushi Noguchi, Hiroshi Miyano,
  "Reference intervals for plasma-free amino acid in a Japanese population" Annals of Clinical Biochemistry, 53 (2016) 357-364.
  [ link (Pubmed)] (⁺ equally contributed)
  
• Hiroo Yoshida, Kazuhiro Kondo, Hiroyuki Yamamoto, Naoko Kageyama, Shin-ichi Ozawa, Kazutaka Shimbo, Takahiko Muramatsu, Akira Imaizumi, Toshimi Mizukoshi, Junichi Masuda, Daisuke Nakayama, Yoshihiro Hayakawa, Kyoko Watanabe, Kazuo Mukaibatake, Hiroshi Miyano,
  "Validation of an analytical method for human plasma free amino acids by high-performance liquid chromatography ionization mass spectrometry using automated precolumn derivatization", Journal of Chromatography B, 998-999 (2015) 88-96.
  [ link ]
• Hiroyuki Yamamoto*, Tamaki Fujimori, Hajime Sato, Gen Ishikawa, Kenjiro Kami, Yoshiaki Ohashi,
  "Statistical hypothesis testing of factor loading in principal component analysis and its application to metabolite set enrichment analysis" BMC Bioinformatics, (2014) 15(1):51.
  [ link (Pubmed) / errata / preprint (older version) / R package / sample code ] (* corresponding author)
  
• Kenjiro Kami, Tamaki Fujimori, Hajime Sato, Mutsuko Sato, Hiroyuki Yamamoto, Yoshiaki Ohashi, Naoyuki Sugiyama, Yasushi Ishihama, Hiroko Onozuka, Taira Kinoshita, Norio Saito, Atsushi Ochiai, Hiroyasu Esumi, Tomoyoshi Soga, Masaru Tomita
  "Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry" Metabolomics, 9(2) (2013) 444-453.
  [ link (Pubmed)]
  
• Hiroyuki Yamamoto, Hideki Yamaji, Yuichiro Abe, Kazuo Harada, Danang Waluyo, Eiichiro Fukusaki, Akihiko Kondo, Hiromu Ohno, Hideki Fukuda,
  "Dimensionality reduction for metabolome data using PCA, PLS, OPLS, and RFDA with differential penalties to latent variables", Chemom. Intell. Lab. Syst., 98 (2009) 136-142.
  [ link ]
  
• Hiroyuki Yamamoto, Hideki Yamaji, Eiichiro Fukusaki, Hiromu Ohno, Hideki Fukuda,
  "Canonical correlation analysis for multivariate regression and its application to metabolic fingerprinting", Biochem. Eng. Journal, 40 (2008) 199-204.
  [ link ]
• Hiroyuki Yamamoto, Keishi Hada, Hideki Yamaji, Tomohisa Katsuda, Hiromu Ohno, Hideki Fukuda,
  "Application of regularized alternating least squares and independent component analysis to HPLC-DAD data of Haematococcus pluvialis metabolites", Biochem. Eng. Journal, 32 (2006) 149-156.
  [ link ]

プロシーディング、総説、その他

• 山本博之, メタボロミクスにおける「質量分析インフォマティクス」
  医学のあゆみ、281(3), 283 - 290 (2022)
  [ link ]
• Hiroyuki Yamamoto, Eisuke Hayakawa, Hiroshi Tsugawa, Yuki Moriya, Eiichiro Fukusaki, Susumu Goto, Tomohisa Hasunuma, Nobuaki Miura, Akiyasu C. Yoshizawa
  "Japan Computational Mass Spectrometry Meeting 2020 Activity Report", Journal of Proteome Data and Methods, 2, 5 (2020)
  [ link ]
• Kenjiro Kami, Tamaki Fujimori, Masanori Terashima, Masatoshi Kusuhara, Masanori Tokunaga, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Hiroyuki Yamamoto, Yoshiaki Ohashi,
  "Metabolomic discrimination of undifferentiated and differentiated gastric cancer.", Cancer Research, 73(8 Supplement), 1867-1867(2013)
  [ link ]
• Masanori Terashima, Masatoshi Kusuhara, Masanori Tokunaga, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Tamaki Fujimori, Hiroyuki Yamamoto, Kenjiro Kami, Yoshiaki Ohashi,
  "Metabolomic discrimination of intestinal-and diffuse-type gastric cancer tissues using capillary electrophoresis time-of-flight mass spectrometry.", Journal of Clinical Oncology, 30(15_suppl), e14635-e14635(2012)
  [ link ]
• Masanori Terashima, Masatoshi Kusuhara, Junya Kondo, Masanori Tokunaga, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Tamaki Fujimori, Hiroyuki Yamamoto, Yoshiaki Ohashi,
  "Metabolome analyses in human gastric cancer tissue using capillary electrophoresis time-of-flight mass spectrometry.", Journal of Clinical Oncology, 30(4_suppl), 61-61(2012)
  [ link ]
• 山本博之, コホート研究と中間形質の解析−網羅的メタボローム解析
  Medical Science Digest, 2011年10月臨時増刊号(特集：分子疫学コホートと新たな予防医学の展開)
  [ link ]
• 山本博之, 多変量解析を用いたメタボロームデータ解析
  The Proceedings of Metabolomics 2nd Ed., Human Metabolome Technologies (2011.12)
  [ link ]

主な口頭発表 (全部)

• 山本博之
  "多変量解析を用いたメタボロームデータ解析における負荷量の活用"
  第16回メタボロームシンポジウム 口頭発表(2022.9)
• 山本博之
  "主成分負荷量とPLS負荷量のためのRパッケージloadings"
  第70回質量分析総合討論会 口頭発表(2022.6)

学会活動

• 質量分析インフォマティクス研究会　世話人
• 加入中の学会 (日本バイオインフォマティクス学会)

その他

• [セミナー] 多変量解析入門　〜ケモメトリックス手法を用いた生物・化学データの解析〜, 情報機構 (2019.4.12)
• [講習会] フリーソフトウェアを通じた多変量解析講習, 第２回メタボロームシンポジウム若手会 (2015.10.3) [資料]
• [セミナー] オミクスデータ解析法, アジレント・テクノロジー株式会社主催メタボロミクスセミナー (2010.2.25-26)
• [記事] メタボロミクスと統計解析, HMTメタブローグ (2009-2010)

趣味

• 鶴岡カフェ部(仮称) Facebook / ウェブサイト
• データ解析コンペ参加